Aminoethyl Nitrate → (2S, 4S)-N-(2-Nitroxyethyl)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide

HRID 373509

Reaktionsgleichung

Reaktionsgleichung von HRID 373509
[O:1]([CH2:5][CH2:6][NH2:7])[N+:2]([O-:4])=[O:3].[F:8][C:9]1[CH:10]=[C:11]2[C@:18]3([C:22](=[O:23])[NH:21][C:20](=[O:24])[NH:19]3)[CH2:17][C@@H:16]([C:25](Cl)=[O:26])[O:15][C:12]2=[CH:13][CH:14]=1>>[O:1]([CH2:5][CH2:6][NH:7][C:25]([C@@H:16]1[CH2:17][C@@:18]2([C:22](=[O:23])[NH:21][C:20](=[O:24])[NH:19]2)[C:11]2[C:12](=[CH:13][CH:14]=[C:9]([F:8])[CH:10]=2)[O:15]1)=[O:26])[N+:2]([O-:4])=[O:3]

Komponenten

3

Edukt 2

HCID 26001Aminoethyl NitrateHCID 57210646(2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carbonyl chloride

Produkt 1

HCID 67944386(2S, 4S)-N-(2-Nitroxyethyl)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamideAusbeute 82,3 %

Versuchsvorschrift

The procedure similar to that as described in Example 8 was carried out with use of 2-nitroxyethylamine and (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carbonyl chloride (Reference Example 1) to give the desired compound.

Quellen und Nachweise

ORD-Eintrag
ord-7f29ef2f5ca4452490e5e7a87a023dc7
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05164391

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