Benzaldehyde → 3,4-dihydro-4,4-dimethyl-6-[(E)-alpha-methylstyryl]-2H-1-benzopyran

HRID 373570Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 373570
[Br-].[CH3:2][C:3]1([CH3:34])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH:13]([P+](C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH3:14])[CH:11]=2)[O:6][CH2:5][CH2:4]1.[CH:35](=O)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1.CO.O>C1OCCC1>[CH3:34][C:3]1([CH3:2])[C:12]2[CH:11]=[C:10](/[C:13](/[CH3:14])=[CH:35]/[C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH:9]=[CH:8][C:7]=2[O:6][CH2:5][CH2:4]1

Komponenten

5

Edukt 3

HCID 240BenzaldehydeHCID 199355281-(4,4-Dimethyl-6-chromanyl)ethyltriphenylphosphonium bromideHCID 22242641Methanol--water (1/1)

Produkt 1

HCID 675909203,4-dihydro-4,4-dimethyl-6-[(E)-alpha-methylstyryl]-2H-1-benzopyranAusbeute 19,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

16.5 g of [1-(4,4-dimethyl-6-chromanyl)ethyl]-triphenylphosphonium bromide and 3 g of benzaldehyde were heated under reflux in 100 ml of butylene oxide for 20 hours. The reaction mixture obtained was poured into a methanol/water mixture (6:4) and extracted with hexane. After drying and evaporating the organic phase the crude product was chromatographed (silica gel, eluting agent hexane) and recrystallized from hexane. There were obtained 1.5 g of 3,4-dihydro-4,4-dimethyl-6-[(E)-α-methylstyryl]-2H-1- benzopyran in the form of colorless crystals, melting point 64°-65° C.

Aufarbeitung

  1. customThe reaction mixture obtained
  2. extractionextracted with hexane
  3. customAfter drying
  4. customevaporating the organic phase the crude product
  5. customwas chromatographed
  6. wash(silica gel, eluting agent hexane)
  7. customrecrystallized from hexane

Quellen und Nachweise

ORD-Eintrag
ord-052ec4539c664136b52a1b77bf52b8a7
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05164387

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