4-Benzyl-2-(methoxymethyl)morpholine → 2-(Methoxymethyl)morpholine

HRID 373916Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 373916
C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][O:15][CH3:16])[CH2:9]1)C1C=CC=CC=1>CO.[C].[Pd]>[CH3:16][O:15][CH2:14][CH:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1

Komponenten

4

Edukt 1

HCID 103534614-Benzyl-2-(methoxymethyl)morpholine

Produkt 1

HCID 149332022-(Methoxymethyl)morpholineAusbeute 86,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysator2×HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

N-Benzyl-2-methoxymethylmorpholine (412.3 g) is dissolved in methanol (2 liters), and thereto is added 10% palladium-carbon (33 g), and the mixture is stirred under hydrogen pressure of 9 kg/cm2 at 100° C. After completion of the reaction, palladium-carbon is filtered off, and the solvent is distilled off under atmospheric pressure to give a pale yellow oily substance. The oily substance is distilled under reduced pressure to give the title compound (212.3 g) as colorless liquid.

Aufarbeitung

  1. filtrationis filtered off
  2. distillationthe solvent is distilled off under atmospheric pressure
  3. customto give a pale yellow oily substance
  4. distillationThe oily substance is distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f606f3d2ef294a8882714e8beb3bcae4
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05166203

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