Hydrochloric Acid → N-[4-(2-pyridylaminocarbonyl)-(S,S)-2,4-dibenzylbutyryl]S-benzyl-(L)-cysteine

HRID 374325Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 374325
C[O:2][C:3](=[O:43])[C@H:4]([CH2:34][S:35][CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)[NH:5][C:6](=[O:33])[C@H:7]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:8][C@H:9]([C:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1)=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[OH-].[Na+].Cl>CO>[N:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[NH:19][C:17]([C@H:9]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:8][C@@H:7]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:6]([NH:5][C@H:4]([C:3]([OH:43])=[O:2])[CH2:34][S:35][CH2:36][C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)=[O:33])=[O:18]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18645479N-[4-(2-pyridylamino-carbonyl)-(S,S)-2,4-dibenzylbutyryl]-S-benzyl-(L)-cysteine methyl ester

Produkt 1

HCID 14997157N-[4-(2-pyridylaminocarbonyl)-(S,S)-2,4-dibenzylbutyryl]S-benzyl-(L)-cysteine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 0.3 g of N-[4-(2-pyridylaminocarbonyl)-(S,S)-2,4-dibenzylbutyryl]-S-benzyl-(L)-cysteine methyl ester and 1 ml of 1N sodium hydroxide in 2 ml of methanol is stirred at room temperature overnight. To the solution is added 1.1 ml of 1N hydrochloric acid. The solution is concentrated, diluted with water, the solid is collected and dried under high vacuum to give N-[4-(2-pyridylaminocarbonyl)-(S,S)-2,4-dibenzylbutyryl]-S-benzyl-(L)-cysteine, melting at 75°-80°; [alpha]D =+22.9°.

Aufarbeitung

  1. concentrationThe solution is concentrated
  2. additiondiluted with water
  3. customthe solid is collected
  4. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-7abb3ba0a48b4b5a9c3c72655e8aafa9
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05166212

Notizen zur Reaktion

Wird geladen…