Sodium Hydroxide → (alphaS)-alpha-Amino-3-thiophenepropanoic acid

HRID 374401Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 374401
[OH-].[Na+].O[C:4](=[CH:8][C:9]1[CH:13]=[CH:12][S:11][CH:10]=1)[C:5]([OH:7])=[O:6].[NH2:14][C@H](C([O-])=O)CC([O-])=O>>[CH:13]1[C:9]([CH2:8][C@H:4]([NH2:14])[C:5]([OH:7])=[O:6])=[CH:10][S:11][CH:12]=1

Komponenten

4

Edukt 3

HCID 14798Sodium HydroxideHCID 5460541l-aspartic acid, sodium saltHCID 57047889Hydroxy-3-(3-thienyl)acrylic acid

Produkt 1

HCID 819083(alphaS)-alpha-Amino-3-thiophenepropanoic acidAusbeute 40 %

Versuchsvorschrift

The procedure was largely as in Example 8. However, solution 1 contained only 20 g of hydroxy-3-(3-thienyl)acrylic acid and 19 g of L-aspartate. The product concentration was 11.5 g/l (58%) after the reaction. After ion-exchange chromatography, 7.9 g (40%) of L-3-(3-thienyl)alanine (2B) were obtained.

Aufarbeitung

  1. customThe product concentration was 11.5 g/l (58%) after the reaction

Quellen und Nachweise

ORD-Eintrag
ord-d33f108946e346f3b68f0b82226d6c52
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05480786

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