Thionyl Chloride → 3-Bromopyridine-4-carbonyl chloride

HRID 374422

Reaktionsgleichung

Reaktionsgleichung von HRID 374422
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]([OH:10])=O.S(Cl)([Cl:13])=O>>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]([Cl:13])=[O:10]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 8179723-Bromoisonicotinic acid

Produkt 1

HCID 135978683-Bromopyridine-4-carbonyl chloride

Versuchsvorschrift

3-Bromopyridine-4-carboxylic acid (5.0 g) was dissolved in thionyl chloride (50 ml) and the solution heated under reflux for 4 hours, cooled and evaporated in vacuo. Re-evaporation of added toluene gave 3-bromopyridine4-carbonyl chloride, m.p.151°-154° C. (dec.) (5.45 g) as a green solid.

Aufarbeitung

  1. temperaturethe solution heated
  2. temperatureunder reflux for 4 hours
  3. temperaturecooled
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f8192f4fac954ba7bd348f63b541c8bf
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05480857

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