N-Acetyl-L-Cysteine → HCID 178418393, Verbindung

HRID 3745

Reaktionsgleichung

Reaktionsgleichung von HRID 3745
[CH3:1][CH:2]([CH2:17][CH3:18])[CH:3]([N:7]1[C:11](=[O:12])[C:10]2[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=2[S:8]1)[C:4]([OH:6])=[O:5].C(N[C@H:23]([C:26]([OH:28])=[O:27])[CH2:24][SH:25])(=O)C>CO>[C:11]([NH:7][SH:25]([CH2:24][CH2:23][C:26]([OH:28])=[O:27])[S:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[C:11]([NH:7][CH:3]([CH:2]([CH3:1])[CH2:17][CH3:18])[C:4]([OH:6])=[O:5])=[O:12])(=[O:12])[CH3:10]

Komponenten

4

Edukt 2

HCID 12035N-Acetyl-L-CysteineHCID 178926623-Methyl-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)pentanoic acid

Produkt 1

HCID 178418393HCID 178418393, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 0.58 g (2.2 mmol) of [S-(R*,R*)]-3-methyl-2-(3-oxo-3H-benzo[d]isothiazol-2-yl)pentanoic acid in 20 mL of methanol was treated with 0.36 g (2.2 mmol) of N-acetyl-L-cysteine and the reaction was stirred at room temperature for 18 hours. The solvent was removed in vacuo and the residue was triturated with 100 mL of 60° C. water. The water was decanted and the solid was dissolved in 50 mL of ethyl acetate. The organic solution was dried (MgSO4), filtered and evaporated in vacuo to give the title compound as a white, solid foam, mp 85°-90° C.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe residue was triturated with 100 mL of 60° C. water
  3. customThe water was decanted
  4. dissolutionthe solid was dissolved in 50 mL of ethyl acetate
  5. dry with materialThe organic solution was dried (MgSO4)
  6. filtrationfiltered
  7. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8b264e10282d462783a148a83796833e
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05734081

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