HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzylamine → cis-8-Benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzylamine | HCID 7504 | — |
| Edukt | trans-1-Benzoyl-3-bromo-4-(2-tosyloxyethoxy)-pyrrolidine | HCID 86748810 | — |
| Lösungsmittel | O-Xylene | HCID 7237 | — |
| Produkt | cis-8-Benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane | HCID 53682667 | — |
Reaktionsschritte
124 g (0.265 mol) of trans-1-benzoyl-3-bromo-4-(2-tosyloxyethoxy)-pyrrolidine are heated under reflux overnight in 1.5 1 of xylene together with 86 g 0.8 mol) of benzylamine. The salts of the benzylamine are filtered off with suction and the filtrate is concentrated.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05480879 |
| Quelldatensatz | uspto-grants-1996_01 |
| ORD ID | ord-198d28caa75146abba072ad94f80ad82 |
| Quellennotiz | uspto-grants-1996_01 |