HCID 18992239, Verbindung → 3-Methyl-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline

HRID 375617Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 375617
[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=S)[N:7]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][C:8]3=[N:9]2)=[CH:4][CH:3]=1>O1CCCC1.[Ni]>[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][N:7]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][C:8]3=[N:9]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 18992239HCID 18992239, Verbindung

Produkt 1

HCID 153377963-Methyl-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a mechanically stirred solution of 5 g of 3-methyl-7,8,9,10-tetrahydroazepino[2,1-b]quinazoline-12(6H)-thione in 150 mL of boiling tetrahydrofuran was added in small portions wet Raney nickel (W-2, Davison Chemical, Chattanooga, Tenn.). The progress of the reaction was followed by TLC. When the reaction was complete, the mixture was filtered, solids on the filter were washed thoroughly with tetrahydrofuran and the filtrate was concentrated down. The rest of the workup was identical to that described in method A.

Aufarbeitung

  1. filtrationthe mixture was filtered
  2. washsolids on the filter were washed thoroughly with tetrahydrofuran
  3. concentrationthe filtrate was concentrated down

Quellen und Nachweise

ORD-Eintrag
ord-92e2953887524df6b32e2ef4598bd23f
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05486512

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