p-Toluenesulfonic acid → 2-(3-Methyl-1,2,4-oxadiazol-5-yl)ethylamine p-toluenesulfonate

HRID 375757Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 375757
[CH3:1][C:2]1[N:6]=[C:5]([CH2:7][CH2:8][NH:9]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[O:4][N:3]=1.[C:29]1([CH3:39])[CH:34]=[CH:33][C:32]([S:35]([OH:38])(=[O:37])=[O:36])=[CH:31][CH:30]=1>C(O)C>[C:29]1([CH3:39])[CH:30]=[CH:31][C:32]([S:35]([OH:38])(=[O:36])=[O:37])=[CH:33][CH:34]=1.[CH3:1][C:2]1[N:6]=[C:5]([CH2:7][CH2:8][NH2:9])[O:4][N:3]=1

Komponenten

4

Edukt 2

HCID 6101p-Toluenesulfonic acidHCID 18992075HCID 18992075, Verbindung

Produkt 1

HCID 189920072-(3-Methyl-1,2,4-oxadiazol-5-yl)ethylamine p-toluenesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 370 mg of [2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethyl]-trityl-amine and 190 mg of p-toluenesulfonic acid in 10 ml of ethanol was heated to 60° C. for 2 hours. The solvent was evaporated and the residue was triturated with diethylether/hexane to give 2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylamine p-toluenesulfonate as white crystals of m.p. 122°-123° C.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue was triturated with diethylether/hexane

Quellen und Nachweise

ORD-Eintrag
ord-4cd20eeb15824b44b6427c2e28af0ea8
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05486466

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