Formaldehyde → 2-(1-Acetylpiperidin-4-yl)propenal

HRID 376140Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 376140
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][OH:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Cl-].[CH3:14][NH2+]C.C=O>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10](=[CH2:14])[CH:11]=[O:12])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 3

HCID 712FormaldehydeHCID 12954980Dimethylazanium;chlorideHCID 21468226Ethanone,1-[4-(2-hydroxyethyl)-1-piperidinyl]-

Produkt 1

HCID 451192142-(1-Acetylpiperidin-4-yl)propenal

Versuchsvorschrift

3.95 g (23.3 mmol) of 2-(1-acetylpiperidin-4-yl)ethanol, 2.12 g (26.3 mmol) of dimethylammonium chloride and 3 ml (40 mmol) of 37% formaldehyde solution are heated at 110° C. for 2 hours with stirring. The mixture is allowed to cool and is extracted several times with diethyl ether. The organic phases are combined, washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and concentrated to dryness by evaporation. 2-(1-acetylpiperidin-4-yl)propenal is obtained in the form of a yellowish oil which can be further reacted without further purification.

Aufarbeitung

  1. temperatureto cool
  2. extractionis extracted several times with diethyl ether
  3. washwashed with saturated sodium chloride solution
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated to dryness by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-22529da802a84b0abbec516a97fb4203
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05488140

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