(5-Methyl-6-methylaminopyridin-2-yl)methanol → 5-Methyl-6-methylamino-2-pyridinecarboxaldehyde
Reaktionsgleichung
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10][OH:11])=[N:6][C:7]=1[NH:8][CH3:9]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH:10]=[O:11])=[N:6][C:7]=1[NH:8][CH3:9]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A suspension of 0.33 g of (5-methyl-6-methylaminopyridin-2-yl)methanol (2.17 mmol) and 1.6 g of manganese dioxide (18.4 mmol) in 12 ml of chloroform is heated under reflux for 1 hour. The insoluble matter is removed by filtration on celite and then the solvent evaporated under vacuum. The title product is purified by chromatography on a silica column (eluent: chloroform). 0.25 g of a yellow solid is recovered.
Aufarbeitung
- temperatureis heated
- temperatureunder reflux for 1 hour
- customThe insoluble matter is removed by filtration on celite
- customthe solvent evaporated under vacuum
- customThe title product is purified by chromatography on a silica column (eluent: chloroform)
- custom0.25 g of a yellow solid is recovered
Quellen und Nachweise
- ORD-Eintrag
- ord-1478e1772b3e4ab19c1c736cf92f7273
- Quelldatensatz
- uspto-grants-2000_02
- Patentnummer
- US06020345
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