Sodium Hydroxide → 5-Hydroxy-2-methoxypyridine

HRID 376358

Reaktionsgleichung

Reaktionsgleichung von HRID 376358
C([O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1)(=O)C.[OH-].[Na+]>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 224515665-Acetoxy-2-methoxypyridine

Produkt 1

HCID 116223355-Hydroxy-2-methoxypyridineAusbeute 53,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of the 5-acetoxy-2-methoxypyridine(600 mg, 3.59 mmol) in MeOH(10 mL) was added 1M aq. NaOH (10 mL, 10 mmol). After stirring at r.t. for 30 min, volatile solvent was removed in vacuo, acidified with HOAc and extracted with CHCl3(3×). The combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and evaporated to give the title compound as a brown oil(240 mg, solidified on standing).

Aufarbeitung

  1. customvolatile solvent was removed in vacuo
  2. extractionextracted with CHCl3(3×)
  3. washThe combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-f79ec0dd0b9e40458cd8ee59575cc942
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06020343

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