1,2-O-dioleyl-3-O-tritylglycerol → 2,3-Bis[(9Z)-9-octadecen-1-yloxy]-1-propanol

HRID 376411

Reaktionsgleichung

Reaktionsgleichung von HRID 376411
[CH2:1]([O:19][CH2:20][CH:21]([CH2:41][O:42]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[O:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]/[CH:31]=[CH:32]\[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>ClC(Cl)(Cl)C(O)=O.C(Cl)Cl>[CH2:1]([O:19][CH2:20][CH:21]([CH2:41][OH:42])[O:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]/[CH:31]=[CH:32]\[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Komponenten

3

Edukt 1

HCID 702527781,2-O-dioleyl-3-O-tritylglycerol

Produkt 1

HCID 53803432,3-Bis[(9Z)-9-octadecen-1-yloxy]-1-propanolAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19349592Trichloroacetic acid methylene chlorideLösungsmittel

Versuchsvorschrift

1,2-O-Dioleyl-3-O-tritylglycerol (6.10 g, 7.3 mmol) was reacted with 5% trichloroacetic acid/methylene chloride (50 ml, w/v) at ambient temperature for 1 hour. The organic layer was then washed with saturated aqueous sodium hydrogen carbonate solution and water, dried, and concentrated. The residue was purified by column chromatography (silica gel/chloroform) to provide 3.75 g (87%) of the title compound.

Aufarbeitung

  1. washThe organic layer was then washed with saturated aqueous sodium hydrogen carbonate solution and water
  2. customdried
  3. concentrationconcentrated
  4. customThe residue was purified by column chromatography (silica gel/chloroform)

Quellen und Nachweise

ORD-Eintrag
ord-b38c504bdc664d459a5be7f3ddc76782
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06020317

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