Ethylmorpholine → 3-Hydroxypyridine-2-carboxylic acid N-(((1-dodecyloxy)carbonyl)methyl)amide

HRID 376438

Reaktionsgleichung

Reaktionsgleichung von HRID 376438
[OH:1][C:2]1[C:3]([C:8]([OH:10])=O)=[N:4][CH:5]=[CH:6][CH:7]=1.ON1C2C=CC=CC=2N=N1.C(N1CCOCC1)C.COS(C1C=CC(C)=CC=1)(=O)=O.C1(N=C=NCCN2CCOCC2)CCCCC1.S(C1C=CC(C)=CC=1)(O)(=O)=O.[CH2:69]([O:81][C:82](=[O:85])[CH2:83][NH2:84])[CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH2:77][CH2:78][CH2:79][CH3:80]>ClCCl>[CH2:69]([O:81][C:82]([CH2:83][NH:84][C:8]([C:3]1[C:2]([OH:1])=[CH:7][CH:6]=[CH:5][N:4]=1)=[O:10])=[O:85])[CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH2:77][CH2:78][CH2:79][CH3:80]

Komponenten

7

Edukt 5

HCID 7525EthylmorpholineHCID 134013-Hydroxypicolinic AcidHCID 757711-HydroxybenzotriazoleHCID 9954069N-cyclohexyl-N'-(2-morpholinoethyl)-carbodiimide methyl-p-toluenesulfonateHCID 15435490Glycine 1-dodecyl ester tosylate

Produkt 1

HCID 98420113-Hydroxypyridine-2-carboxylic acid N-(((1-dodecyloxy)carbonyl)methyl)amide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

7 g (50 mmol) of 3-hydroxypyridine-2-carboxylic acid were suspended in 800 ml of anhydrous dichloromethane and treated with 7.5 g (55 mmol) of 1-hydroxy-1H-benzotriazole, 19.2 ml (150 mmol) of N-ethylmorpholine, 21.2 g (50 mmol) of N-cyclohexyl-N'-(2-morpholinoethyl)carbodiimide methyl-p-toluenesulfonate (CMC) and 20.8 g (50 mmol) of glycine 1-dodecyl ester tosylate and the mixture was stirred at 20° C. for 50 h.

Quellen und Nachweise

ORD-Eintrag
ord-015e862b3cb0448ab6bfcf1d5e1d4c92
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06020350

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