Dichloromethane → 1-Cycloheptyl-1-(6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl)-3-[p-(N,N-dimethylamino)phenyl]urea monohydrochloride

HRID 37645

Reaktionsgleichung

Reaktionsgleichung von HRID 37645
[CH:1]1([NH:8][C:9]2[C:14]3[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[CH:12]=[CH:11][CH:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:20][N:21]([C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[O:31])=[CH:25][CH:24]=1)[CH3:22].[Cl:32]CCl>>[ClH:32].[CH:1]1([N:8]([CH:9]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:19][C:18]=3[CH2:17][CH2:16][CH2:15][CH2:14]2)[C:30]([NH:29][C:26]2[CH:27]=[CH:28][C:23]([N:21]([CH3:22])[CH3:20])=[CH:24][CH:25]=2)=[O:31])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Komponenten

4

Edukt 3

HCID 6344DichloromethaneHCID 27333724-(Dimethylamino)phenyl isocyanateHCID 19936134N-Cycloheptyl-(6,7,8,9-tetrahydro-5H-benzocycloheptenyl)amine

Produkt 1

HCID 197856731-Cycloheptyl-1-(6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl)-3-[p-(N,N-dimethylamino)phenyl]urea monohydrochloride

Versuchsvorschrift

N-Cycloheptyl-(6,7,8,9-tetrahydro-5H-benzocycloheptenyl)amine (0.8 g, 3.1 mmol) and 4-(N,N-dimethyamino)phenylisocyanate (0.50 g, 3.1 mmol) was stirred in dichloromethane (10 ml) at room temperature for 18 hrs. The reaction mixture was then purified by silica gel column chromatography. The resulting urea compound was treated with hydrochloric acid in ether to give 0.72 g of the above hydrochloride compound.

Aufarbeitung

  1. customThe reaction mixture was then purified by silica gel column chromatography
  2. additionThe resulting urea compound was treated with hydrochloric acid in ether

Quellen und Nachweise

ORD-Eintrag
ord-b7fec6b979644c45868240396b343456
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05420348

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