Gadolinium → Gadobutrol (JAN/USAN/INN)
Reaktionsgleichung
[Na+].[N:2]1([CH2:22][C:23]([O-:25])=[O:24])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][N:8]([CH2:14][C:15]([O-:17])=[O:16])[CH2:7][CH2:6][N:5]([CH2:18][C:19]([O-:21])=[O:20])[CH2:4][CH2:3]1.[Na+].[Na+].CC1(C)[O:36][CH2:35][CH:34]2[CH:32]([O:33]2)[CH2:31][O:30]1.[Gd:38]>>[CH2:4]1[N:5]([CH2:18][C:19]([O-:21])=[O:20])[CH2:6][CH2:7][N:8]([CH2:14][C:15]([O-:17])=[O:16])[CH2:9][CH2:10][N:11]([CH:34]([CH:32]([OH:33])[CH2:31][OH:30])[CH2:35][OH:36])[CH2:12][CH2:13][N:2]([CH2:22][C:23]([O-:25])=[O:24])[CH2:3]1.[Gd+3:38]Komponenten
4
Versuchsvorschrift
The solution of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid sodium salt is directly reacted, as described in EP 448191, with 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane to give the alkylated product, which can, easily be complexed with gadolinium to give the final Gadobutrol.