HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methyl chloroformate → 2-Methyl-1-naphthol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methyl chloroformate | HCID 6586 | — |
| Edukt | 1-Hydroxy-2-naphthoic acid | HCID 6844 | — |
| Edukt | 1-Naphthol | HCID 7005 | — |
| Edukt | Sodium borohydride | HCID 4311764 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 2-Methyl-1-naphthol | HCID 24055 | 80% |
Reaktionsschritte
1-naphthol (5) was heated with twice its weight of KHCO3 at 200° C. for 5 hours (stainless steel bomb) whereby 1-hydroxy-2-naphthoic acid (9) was obtained in a yield of 60%. 1-Hydroxy-2-naphthoic acid (9) was treated with methyl chloroformate and triethylamine in THF, followed by sodium borohydride reduction, whereby 2-methyl-naphthol (I) was produced in a yield of 80%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05420362 |
| Quelldatensatz | uspto-grants-1995_05 |
| ORD ID | ord-9268980dbcd94c068c537f2d13247f9b |
| Quellennotiz | uspto-grants-1995_05 |