Potassium Carbonate → 2-(1,2-Epoxycyclohexyl)-4,5-diphenyloxazole

HRID 377313Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 377313
Br[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1([C:9]1[O:10][C:11]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:13]=1)[OH:8].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:8]1[CH:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C:3]12[C:9]1[O:10][C:11]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:13]=1

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 193585162-Bromo-1-(4,5-diphenyl-2-oxazolyl)cyclohexanol

Produkt 1

HCID 184591642-(1,2-Epoxycyclohexyl)-4,5-diphenyloxazoleAusbeute 98,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 2-bromo-1-(4,5-diphenyl-2-oxazolyl)-cyclohexanol (120 mg) and potassium carbonate (83 mg) in N,N-dimethylformamide (0.3 ml) was stirred at room temperature for 6 hours and partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated in vacuo to afford 2-(1,2-epoxycyclohexyl)-4,5-diphenyloxazole (94 mg) as a pale yellow powder.

Aufarbeitung

  1. custompartitioned between ethyl acetate and water
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6f715285732440fca41c8f5f3e33e817
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06025375

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