HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Glyceraldehyde → Ethyl acetate methanol ammonium hydroxide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Glyceraldehyde | HCID 751 | — |
| Edukt | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Edukt | 2-[4-(2-Aminoethyl)phenyl]-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene | HCID 22462716 | — |
| Lösungsmittel | Dichloromethane methanol | HCID 21226129 | — |
| Produkt | Ethyl acetate methanol ammonium hydroxide | HCID 21901312 | — |
Reaktionsschritte
3-[4-[2-(1-Pyrrolidinyl)ethoxy]benzyl]-2-[4-(2-aminoethyl)phenyl]benzo[b]thiophene (113 mg) was dissolved in dichloromethane:methanol (2:1, 6.0 mL), treated with glyceraldehyde (25 mg) and sodium triacetoxyborohydride (60 mg) sequentially and allowed to stir at ambient temperature for 4 h. The reaction mixture was concentrated, and column chromatography with NH4OH:MeOH:EtOAc (3:7:90) afforded the product (56 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06025382 |
| Quelldatensatz | uspto-grants-2000_02 |
| ORD ID | ord-1a415f14033b4c91b21f175517078ddb |
| Quellennotiz | uspto-grants-2000_02 |