Phosphorus oxychloride → 1-Phenyl-2-(3,4-dimethylphenyl)-6-methoxybenzimidazole

Beteiligte Stoffe

Reaktionsschritte

The nitro group of the above-described intermediate was then reduce to an amino group by catalytic hydrogenation using a palladium on activated carbon catalyst, essentially as previously described, resulting in 3-phenylamino-4-methoxyaniline with was then reacted with 3,4-dimethylbenzoyl chloride as previously described. This intermediate was then cyclized to the corresponding benzimidazole with phosphorous oxychloride as previously described to yield 1-phenyl-2-(3,4-dimethylphenyl )-6-methoxybenzimidazole.

Herkunft & Nachweise