Hydrazine → Pyrazine-2-Carboxylic Acid Hydrazide

HRID 378833

Reaktionsgleichung

Reaktionsgleichung von HRID 378833
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9]C)=O.[NH2:11][NH2:12]>CO>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH:11][NH2:12])=[O:9]

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 72662Methyl pyrazinoate

Produkt 1

HCID 258796Pyrazine-2-Carboxylic Acid Hydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of the product from Example 1 step c) (22 g, 159 mmol) in methanol (250 ml) was slowly added hydrazine monhydrate (36.6 ml, 710 mmol). The reaction mixture was stirred for 1.5 h. The precipitate produced was filtered, washed with diethyl ether and dried in the oven at 80° C. to give the required product (30 g). 1H NMR (250 MHz, DMSO) δ 4.66 (2H, broad peak), 8.66 (1H, m), 8.84 (1H, d, J=2.5 Hz), 9.13 (1H, d, J=2.5 Hz), 10.15 (1H, broad peak); MS (ES+) m/e 139 [MH+].

Aufarbeitung

  1. customThe precipitate produced
  2. filtrationwas filtered
  3. washwashed with diethyl ether
  4. customdried in the oven at 80° C.

Quellen und Nachweise

ORD-Eintrag
ord-8880dd93059d499192c4c6be784ff1e1
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06297235B1

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