1-Methylhomopiperazine → 5-Chloro-2-(4-methyl-1-homopiperazinyl)benzoxazole

HRID 378889Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 378889
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](S)=[N:7][C:6]=2[CH:11]=1.[CH3:12][N:13]1[CH2:19][CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N:16]3[CH2:17][CH2:18][CH2:19][N:13]([CH3:12])[CH2:14][CH2:15]3)=[N:7][C:6]=2[CH:11]=1

Komponenten

4

Edukt 2

HCID 2283491-MethylhomopiperazineHCID 178527795HCID 178527795, Verbindung

Produkt 1

HCID 105636585-Chloro-2-(4-methyl-1-homopiperazinyl)benzoxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

5-Chloro-2-mercaptobenzoxazole (1 g) was dissolved in toluene (50 ml), N-methylhomopiperazine (3.3 ml) was added dropwise to the solution and then the mixture was stirred with heating for 2 hours. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1) to obtain the title compound 5-chloro-2-(4-methyl-1-homopiperazinyl)benzoxazole (882 mg).

Aufarbeitung

  1. temperaturewith heating for 2 hours
  2. customAfter evaporation of the solvent
  3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1)

Quellen und Nachweise

ORD-Eintrag
ord-f90cec8b414c4651a73749925dfd010c
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06297246B1

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