Imidazole → 2-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

HRID 379031Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 379031
Br[CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([OH:11])[CH:4]=1.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1>CN(C=O)C>[OH:11][C:5]1[CH:4]=[C:3]([CH2:2][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:10]=[CH:9][C:6]=1[C:7]#[N:8]

Komponenten

4

Edukt 2

HCID 795ImidazoleHCID 216969934-(Bromomethyl)-2-hydroxybenzonitrile

Produkt 1

HCID 216970282-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-bromomethyl-2-hydroxy-benzonitrile (0.22 g, 1.05 mmol) and imidazole (0.36 g, 5.23 mmol) were dissolved in DMF (10 mL) with stirring at ambient temperature. After stirring for 18 h, the reaction mixture was concentrated in vacuo and purified by silica gel chromatography eluting with 2% CH3OH/CH2C12 to 5% CH3OH/CH2Cl2 to give the title compound.

Aufarbeitung

  1. stirringAfter stirring for 18 h
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. custompurified by silica gel chromatography
  4. washeluting with 2% CH3OH/CH2C12 to 5% CH3OH/CH2Cl2

Quellen und Nachweise

ORD-Eintrag
ord-b0d36694988949c584188e150db9557d
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06297239B1

Notizen zur Reaktion

Wird geladen…