Potassium Carbonate → 2(1H)-Pyridinone, 1-(2-methoxyphenyl)-

HRID 379072

Reaktionsgleichung

Reaktionsgleichung von HRID 379072
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[OH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1.C([O-])([O-])=O.[K+].[K+]>[Cu].CCOC(C)=O>[O:10]=[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]1[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9]

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 68257o-IodoanisoleHCID 178516071HCID 178516071, Verbindung

Produkt 1

HCID 121913892(1H)-Pyridinone, 1-(2-methoxyphenyl)-

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23978CopperKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
200 °C

Versuchsvorschrift

2-Iodoanisole (1.30 mL, 0.01 mol), 2-hydroxypyridine (0.95 g, 0.01 mol), anhydrous K2CO3 (2.76 g, 0.02 mol) and copper powder (0.0636 g, 0.001 mol) were combined and heated at 200° C. for 2 hr. The reaction mixture was cooled, EtOAc added, and filtered. The filtrate was washed with H2O, aqueous saturated NaHCO3 solution, brine, and dried (Na2SO4). Filtration and concentration gave the title compound after chromatography (silica gel, 2% CH3OH, CH2Cl2).

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. filtrationfiltered
  3. washThe filtrate was washed with H2O, aqueous saturated NaHCO3 solution, brine
  4. dry with materialdried (Na2SO4)
  5. filtrationFiltration and concentration

Quellen und Nachweise

ORD-Eintrag
ord-4c3a55ba796041aab00b78a70ae21ba3
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06297239B1

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