3-Aminoazetidine, 3-BOC protected → tert-Butyl {1-[6-(5-oxo-4-pyridin-3-yl-2,5-dihydro-1H-pyrazol-1-yl)pyrimidin-4-yl]azetidin-3-yl}-carbamate

HRID 37911

Reaktionsgleichung

Reaktionsgleichung von HRID 37911
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[C:12](=[O:13])[C:11]([C:14]3[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=3)=[CH:10][NH:9]2)[CH:3]=1.[NH:20]1[CH2:23][CH:22]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH2:21]1>C(O)C>[O:13]=[C:12]1[N:8]([C:4]2[N:5]=[CH:6][N:7]=[C:2]([N:20]3[CH2:23][CH:22]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:29])([CH3:28])[CH3:30])[CH2:21]3)[CH:3]=2)[NH:9][CH:10]=[C:11]1[C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1

Komponenten

4

Edukt 2

HCID 15194053-Aminoazetidine, 3-BOC protectedHCID 866723282-(6-Chloropyrimidin-4-yl)-4-pyridin-3-yl-1,2-dihydro-3H-pyrazol-3-one

Produkt 1

HCID 70302327tert-Butyl {1-[6-(5-oxo-4-pyridin-3-yl-2,5-dihydro-1H-pyrazol-1-yl)pyrimidin-4-yl]azetidin-3-yl}-carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

200 mg (0.7 mmol) of the compound from Example 23 and 252 mg (1.5 mmol) of tert-butyl azetidin-3-ylcarbamate are suspended in 6 ml of ethanol and reacted at 120° C. in a single-mode microwave oven (CEM Explorer) for 40 min. The solid formed is filtered off, washed twice with in each case 0.5 ml of ethanol and dried under high vacuum.

Aufarbeitung

  1. customreacted at 120° C. in a single-mode microwave oven (CEM Explorer) for 40 min
  2. customThe solid formed
  3. filtrationis filtered off
  4. washwashed twice with in each case 0.5 ml of ethanol
  5. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-61ffad6f04f34b6db1d26cca5588c567
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524699B2

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