Dichloromethane → HCID 54440811, Verbindung

HRID 379270Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 379270
O=[C:2]([CH3:11])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[O:10].[C:12](C=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:14][CH2:15][CH3:16])=[O:13].[CH2:37](Cl)Cl>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9](=[O:10])[CH3:37])[CH3:16]

Komponenten

4

Edukt 3

HCID 6344Dichloromethane2×HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 109316848-Oxo-nonanal

Produkt 1

HCID 54440811HCID 54440811, Verbindung

Versuchsvorschrift

To a cooled (−40° C.) solution of 28-2 (10.8 g, 69.2 mmol) in 150 mL CH2Cl2 was added (carbethoxymethylene)triphenylphosphorane (24.1 g, 69.2 mmol) in 100 mL CH2Cl2 gradually over 15 min. The reaction mixture was stirred for 12 hr while it was warmed up to room temperature. After solvent removal, the residue was purified using silica gel flash chromatography (EtOAc/hexanes: 1:8 to 1:6) to afford the desired product 28-3 as an oil.

Aufarbeitung

  1. customAfter solvent removal
  2. customthe residue was purified

Quellen und Nachweise

ORD-Eintrag
ord-42dd264970e94fbf89d67c8092ec7d18
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06297249B1

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