Thionyl Chloride → HCID 18366631, Verbindung

HRID 379583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 379583
S(Cl)([Cl:3])=O.O[CH2:6][C:7]1[S:22][C:10]2[N:11]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:12](=[O:17])[N:13]([CH3:16])[C:14](=[O:15])[C:9]=2[C:8]=1[C:23]([N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:24]>ClCCl>[Cl:3][CH2:6][C:7]1[S:22][C:10]2[N:11]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:12](=[O:17])[N:13]([CH3:16])[C:14](=[O:15])[C:9]=2[C:8]=1[C:23]([N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:24]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 18366607HCID 18366607, Verbindung

Produkt 1

HCID 18366631HCID 18366631, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Thionyl chloride (0.046 ml) was added to a solution of 1-{[1,2,3,4-tetrahydro-6-(hydroxymethyl)-3-methyl-1-(2-methylpropyl)-2,4-dioxothieno[2,3-d]pyrimidin-5-yl]carbonyl }pyrrolidine (0.1 15 g) in anhydrous dichloromethane (5 ml) under nitrogen. After 1 hour, the mixture was evaporated. The residue was redissolved in ethyl acetate (25 ml), washed with saturated aqueous sodium bicarbonate solution, dried over anhydrous magnesium sulfate, filtered and evaporated to give the subtitle compound (0.11 g) as an oil.

Aufarbeitung

  1. customthe mixture was evaporated
  2. dissolutionThe residue was redissolved in ethyl acetate (25 ml)
  3. washwashed with saturated aqueous sodium bicarbonate solution
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5f4b79f441034d07a5506712aa37ee47
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06300334B1

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