Morpholine → (R)-2-Hydroxy-1-morpholinopropan-1-one

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of methyl (R)-lactate (175 g) and morpholine (440 ml, 3 eq) was heated at 85° C. for 40 h. The mixture was evaporated under reduced pressure. Purification of the residue by silica gel chromatography (using n-hexane:ethyl acetate=1:1 ˜ethyl acetate as an eluent) gave 4-[(R)-2-hydroxypropionyl]morpholine (232.4 g, 87% yield) as a pale yellow oil.

Herkunft & Nachweise