6-Amino1-[3-(4-cyano-phenyl)propionyl]-1,2,3,4-tetrahydro-quinoline → 1-[3-(4-Cyano-phenyl)propionyl]-6-(4-amino-3,5-dichloro-phenyl-sulphonamido)-1,2,3,4-tetrahydro-quinoline

HRID 379680Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 379680
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:12](=[O:23])[CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[CH:17][CH:16]=1)[CH2:7][CH2:6][CH2:5]2.[NH2:24][C:25]1[C:30]([Cl:31])=[CH:29][C:28]([S:32](Cl)(=[O:34])=[O:33])=[CH:27][C:26]=1[Cl:36]>N1C=CC=CC=1>[C:21]([C:18]1[CH:17]=[CH:16][C:15]([CH2:14][CH2:13][C:12]([N:8]2[C:9]3[C:4](=[CH:3][C:2]([NH:1][S:32]([C:28]4[CH:29]=[C:30]([Cl:31])[C:25]([NH2:24])=[C:26]([Cl:36])[CH:27]=4)(=[O:34])=[O:33])=[CH:11][CH:10]=3)[CH2:5][CH2:6][CH2:7]2)=[O:23])=[CH:20][CH:19]=1)#[N:22]

Komponenten

4

Edukt 2

HCID 154107726-Amino1-[3-(4-cyano-phenyl)propionyl]-1,2,3,4-tetrahydro-quinolineHCID 189759814-Amino-3,5-dichlorobenzene-1-sulfonyl chloride

Produkt 1

HCID 154107761-[3-(4-Cyano-phenyl)propionyl]-6-(4-amino-3,5-dichloro-phenyl-sulphonamido)-1,2,3,4-tetrahydro-quinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

1.0 g 6-amino-1-[3-(4-cyano-phenyl)propionyl]-1,2,3,4-tetrahydro-quinoline (see Example, 5) are dissolved in 8 ml of pyridine, combined with 1 g of 4-amino-3,5-dichloro-phenylsulphonic acid chloride in batches and then heated for 40 minutes to 100° C. Then the solvent is eliminated, the residue is triturated with 1N hydrochloric acid and extracted with methylene chloride. The organic phase is dried over sodium sulphate and concentrated by evaporation.

Aufarbeitung

  1. temperatureheated for 40 minutes to 100° C
  2. customthe residue is triturated with 1N hydrochloric acid
  3. extractionextracted with methylene chloride
  4. dry with materialThe organic phase is dried over sodium sulphate
  5. concentrationconcentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-f0751c7240fd4926a769eea56a05247b
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06300342B1

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