(1s,4r)-4-Propylcyclohexane-1-carboxylic acid → 4-Ethynyl-4'-propylbicyclohexyl-4-yl 4-propylcyclohexanecarboxylate

Beteiligte Stoffe

Reaktionsschritte

4.00 g of 4-(dimethylamino)pyridine are added to a solution of 16.00 g of 4-ethynyl-4′-propylbicyclohexyl-4-ol and 11.51 g of 4-propylcyclohexanecarboxylic acid in 120 ml of dichloromethane. 9.66 g of N,N-dicyclohexylcarbodiimide in 30 ml of methylene chloride are subsequently added dropwise at RT, and the mixture is stirred overnight. Conventional work-up gives 4-ethynyl-4′-propylbicyclohexyl-4-yl 4-propylcyclohexane-carboxylate (C 59 N 120 I, Δε−1.57, Δn 0.04).

Herkunft & Nachweise