Potassium Carbonate → 2-(4-[4-(4,5-Dichloro-2-methylimidazol-1-yl)butyl]piperazin-1-yl}-5-fluoropyrimidine

HRID 380327

Reaktionsgleichung

Reaktionsgleichung von HRID 380327
[F:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:17][CH2:16][N+:11]3([CH2:15][CH2:14][CH2:13][CH2:12]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[Cl:18][C:19]1[N:20]=[C:21]([CH3:25])[NH:22][C:23]=1[Cl:24].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:18][C:19]1[N:20]=[C:21]([CH3:25])[N:22]([CH2:12][CH2:13][CH2:14][CH2:15][N:11]2[CH2:10][CH2:9][N:8]([C:5]3[N:6]=[CH:7][C:2]([F:1])=[CH:3][N:4]=3)[CH2:17][CH2:16]2)[C:23]=1[Cl:24]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 3123904,5-Dichloro-2-methyl-1H-imidazoleHCID 120447898-(5-Fluoro-2-pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane

Produkt 1

HCID 98083422-(4-[4-(4,5-Dichloro-2-methylimidazol-1-yl)butyl]piperazin-1-yl}-5-fluoropyrimidineAusbeute 85,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 3.17 g (0.01 mol) of 8-(5-fluoro-2-pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane, 2.26 g (0.015 mol) of 4,5-dichloro-2-methyl-1H-imidazole and 76 g (0.02 mol) of potassium carbonate in 80 ml of dimethylformamide is maintained at reflux for 12 hours. The mixture is subsequently evaporated to dryness and the resulting crude product is redissolved in chloroform and washed repeatedly with water. The organic phase is dried and evaporated, and then the resulting crude product is purified by chromatography on a column of silica gel. 3.3 g (85% yield) of 2-{4-[4-(4,5-dichloro-2-methylimidazol-1-yl)butyl]piperazin-1-yl)-5-fluoropyrimidine are obtained in the form of an oil.

Aufarbeitung

  1. temperatureis maintained
  2. temperatureat reflux for 12 hours
  3. customThe mixture is subsequently evaporated to dryness
  4. dissolutionthe resulting crude product is redissolved in chloroform
  5. washwashed repeatedly with water
  6. customThe organic phase is dried
  7. customevaporated
  8. customthe resulting crude product is purified by chromatography on a column of silica gel

Quellen und Nachweise

ORD-Eintrag
ord-48864279ec2d462a99cfff8aa3603e16
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06303608B1

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