Lawesson's reagent → 3-Amino-2-thiophenecarbothioamide

HRID 380394

Reaktionsgleichung

Reaktionsgleichung von HRID 380394
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH2:9])=O.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:19])=CC=1>O1CCCC1>[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7](=[S:19])[NH2:9]

Komponenten

4

Edukt 2

HCID 87949Lawesson's reagentHCID 5189933-Aminothiophene-2-carboxamide

Produkt 1

HCID 143211023-Amino-2-thiophenecarbothioamideAusbeute 57,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 3-aminothiophene-2-carboxamide (4.5 g, 31 mmol) in tetrahydrofuran was treated with Lawesson's Reagent (7.7 g, 190 mmol) and the solution was stirred at room temperature for 18 h. The solvent was removed and the residue purified by chromatography on silica gel using dichloromethane as eluent. The product was obtained as a yellow powder (2.8 g, 56%), m.p. 98-99° C.

Aufarbeitung

  1. customThe solvent was removed
  2. customthe residue purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-b8dbf243a8a842919d2cafadcf065e20
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06303613B1

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