Triethylamine → 2,4-Dichloro-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

HRID 38046

Reaktionsgleichung

[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([C:9](Cl)=[O:10])=[CH:4][N:3]=1.[F:12][C:13]([F:17])([F:16])[CH2:14][NH2:15].C(N(CC)CC)C>C(Cl)Cl>[F:12][C:13]([F:17])([F:16])[CH2:14][NH:15][C:9]([C:5]1[C:6]([Cl:8])=[N:7][C:2]([Cl:1])=[N:3][CH:4]=1)=[O:10]

Komponenten

Reaktionsbedingungen

Temperatur: 25 °C

Versuchsvorschrift

2,4-Dichloropyrimidine-5-carbonyl chloride (1 g, 5 mmol) was dissolved in CH2Cl2 (20 mL), 2,2,2-trifluoroethylamine (515 mg, 5 mmol) and triethylamine (1.31 mL, 9 mmol) were added. The reaction mixture was stirred at 25° C. for 2 h. The reaction mixture was purified by flash chromatography to yield a white solid (780 mg, 60%). MS: m/z=271.9 [M−H]−.

Aufarbeitung

customThe reaction mixture was purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag: ord-e3e74a819e39477187627512570c9e67
Quelldatensatz: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08524710B2

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