methyl [6-chloro-2-[(5,6,7,8-tetrahydroisoquinolin-3-yl)carbonyl]-1H-indol-3-yl]acetate → Methyl [6-chloro-2-[(2,3-dihydro-1-benzofuran-5-yl)carbonyl]1H-indol-3-yl]acetate

HRID 380564Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 380564
Br[CH2:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][CH2:11][CH2:10][C:9]=2[CH:13]=1)=[O:4].[Cl:14][C:15]1[CH:23]=[C:22]2[C:18]([C:19]([CH2:36][C:37]([O:39][CH3:40])=[O:38])=C(C(C3N=CC4CCCCC=4C=3)=O)[NH:21]2)=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:23]=[C:22]2[C:18]([C:19]([CH2:36][C:37]([O:39][CH3:40])=[O:38])=[C:2]([C:3]([C:5]3[CH:6]=[CH:7][C:8]4[O:12][CH2:11][CH2:10][C:9]=4[CH:13]=3)=[O:4])[NH:21]2)=[CH:17][CH:16]=1

Komponenten

3

Edukt 2

HCID 9908023methyl [6-chloro-2-[(5,6,7,8-tetrahydroisoquinolin-3-yl)carbonyl]-1H-indol-3-yl]acetateHCID 101057272-Bromo-1-(2,3-dihydro-1-benzofuran-5-yl)ethan-1-one

Produkt 1

HCID 9951231Methyl [6-chloro-2-[(2,3-dihydro-1-benzofuran-5-yl)carbonyl]1H-indol-3-yl]acetate

Versuchsvorschrift

The title compound was prepared according to the procedure described in step 2 of Example 1 from 5-bromoacetyl-2,3-dihydro-1-benzofuran* and methyl trans-4-chloro-2-[(Phenylsulfonyl)amino]cinnamate (Example 1, step 1).

Quellen und Nachweise

ORD-Eintrag
ord-6f9125bca28f4c99acc33ee5ebca19e8
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06303628B1

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