Thionyl Chloride → 4-(3-Methylbutoxy)benzene-1-sulfonyl chloride

HRID 380580Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 380580
[CH:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([S:15]([O-:18])(=O)=[O:16])=[CH:11][CH:10]=2)[CH2:5]CC[CH2:2]1.[Na+].S(Cl)([Cl:22])=O>CN(C)C=O>[CH3:2][CH:1]([CH3:5])[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([Cl:22])(=[O:18])=[O:16])=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 23697515Sodium 4-(2-cyclopentylethoxy)benzenesulfonate

Produkt 1

HCID 183240014-(3-Methylbutoxy)benzene-1-sulfonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideKatalysator

Versuchsvorschrift

A mixture of sodium 4(2-cyclopentylethoxy)-benzenesulfonate (2.5 grams, 8.6 mmole), thionyl chloride (15 mL), and a few drops of N,N-dimethylformamide was heated at reflux for 5 hours. After cooling, the excess thionyl chloride was evaporated and the residue was taken up in ethyl acetate. The solution was cooled in an ice bath and water was added. The organic phase was separated and washed with water and brine. After drying over sodium sulfate, the solvent was evaporated to afford the titled compound as an oil, 2.24 grams (90%).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 5 hours
  3. temperatureAfter cooling
  4. customthe excess thionyl chloride was evaporated
  5. temperatureThe solution was cooled in an ice bath
  6. additionwater was added
  7. customThe organic phase was separated
  8. washwashed with water and brine
  9. dry with materialAfter drying over sodium sulfate
  10. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-7761effdde63479bb1fe6ea6e3301f77
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06303636B1

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