tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate → (S)-N-Boc-2-ethynylpyrrolidine

Beteiligte Stoffe

Reaktionsschritte

(S)-N-Boc-2-Ethynyl-pyrrolidine was prepared according to Method X above by the treatment of (S)-N-Boc-2-formyl-pyrrolidine (470 mg, 2.36 mmol) (Example 87A above) with potassium tert-butoxide (340 mg, 3.07 mmol) and diazomethyl-phosphonic-acid-diethylester (550 mg, 3.07 mmol) (also prepared according to Method X). The product was obtained after silica gel column chromatography with 10% Et2O in hexanes. (Yield 200 mg, 43%).

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