HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → HCID 22467245, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Ethanaminium, N,N,N-triethyl-, fluoride (1:1) | HCID 69582 | — |
| Edukt | 3-{1-(1,3-Benzodioxol-5-yl)-2-[(2-ethyl-4-methylphenyl)sulfonamido]-2-oxoethyl}-6-(triisopropylsilyloxymethyl)-1-methyl-1h-indole | HCID 22467246 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | HCID 22467245 | HCID 22467245 | 84,5% |
Reaktionsschritte
Tetraethylammonium fluoride (312 mg, 2.18 mmol) was added to a stirred solution of the compound of step (g) (380 mg, 0.55 mmol) in acetonitrile (6 ml) at room temperature under a nitrogen atmosphere. After 12 H the mixture was poured into 1M hydrochloric acid (50 ml) and extracted into ethyl acetate (2×50 ml). The organic fractions were combined, dried (MgSO4) and concentrated in vacuo to give a yellow foam. Flash column chromatography (eluting with 98% dichloromethane/2% methanol) gave the product as a white solid (242 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06306852B1 |
| Quelldatensatz | uspto-grants-2001_10 |
| ORD ID | ord-23cd5a78594f423b8c469eb4457657cd |
| Quellennotiz | uspto-grants-2001_10 |