HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Phosgene → HCID 178481179, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Phosgene | HCID 6371 | — |
| Edukt | Piperidine | HCID 8082 | — |
| Edukt | Ethyl orthoformate | HCID 31214 | — |
| Edukt | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| Edukt | Methane, sulfinylbis-, ion(1-), sodium | HCID 10154010 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Produkt | HCID 178481179 | HCID 178481179 | — |
Reaktionsschritte
starting with 4-fluoroanthranilic acid comprising cyclization with phosgene to create an intermediate -A, followed by methylation to create an intermediate -B, then by reaction with dimsyl sodium to create an intermediate -C, then by reaction with triethyl orthoformate in the presence of piperdine and acetic acid to give flosequinan. The overall yield of the disclosed process is greater than about 16%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06307050B1 |
| Quelldatensatz | uspto-grants-2001_10 |
| ORD ID | ord-9604846a8b2848ef94d287caf71cf1df |
| Quellennotiz | uspto-grants-2001_10 |