Ethylene Glycol → Simvastatin

Beteiligte Stoffe

Reaktionsschritte

Simvastatin boronate (III) is heated in the presence of a suitable diol solvent selected from ethylene glycol, 1,3-propanediol, or neopentyl glycol, under thermal conditions. The product is isolated by concentration of the reaction mixture, dilution with water, and extraction with an organic solvent. The organic solvent is concentrated to a minimum volume and simvastatin is isolated by the addition of a cosolvent and filtration.

Herkunft & Nachweise