Ethylene Glycol → Simvastatin

HRID 381709

Reaktionsgleichung

Reaktionsgleichung von HRID 381709
[CH3:1][CH2:2][C:3]([C:6]([O:8][C@@H:9]1[C@@H:14]2[C@@H:15]([CH2:20][CH2:21][C@H:22]3[O:28][C:26](=[O:27])[CH2:25][C@H:24]([OH:29])[CH2:23]3)[C@@H:16]([CH3:19])[CH:17]=[CH:18][C:13]2=[CH:12][C@H:11]([CH3:30])[CH2:10]1)=[O:7])([CH3:5])[CH3:4].B([O-])[O-].C(O)CO.C(O)CCO.OCC(C)(CO)C>O>[CH3:1][CH2:2][C:3]([C:6]([O:8][C@@H:9]1[C@@H:14]2[C@@H:15]([CH2:20][CH2:21][C@H:22]3[O:28][C:26](=[O:27])[CH2:25][C@H:24]([OH:29])[CH2:23]3)[C@@H:16]([CH3:19])[CH:17]=[CH:18][C:13]2=[CH:12][C@H:11]([CH3:30])[CH2:10]1)=[O:7])([CH3:5])[CH3:4]

Komponenten

6

Edukt 4

HCID 174Ethylene GlycolHCID 104421,3-PropanediolHCID 31344Neopentyl glycolHCID 178445512HCID 178445512, Verbindung

Produkt 1

HCID 54454Simvastatin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Simvastatin boronate (III) is heated in the presence of a suitable diol solvent selected from ethylene glycol, 1,3-propanediol, or neopentyl glycol, under thermal conditions. The product is isolated by concentration of the reaction mixture, dilution with water, and extraction with an organic solvent. The organic solvent is concentrated to a minimum volume and simvastatin is isolated by the addition of a cosolvent and filtration.

Aufarbeitung

  1. concentrationThe organic solvent is concentrated to a minimum volume

Quellen und Nachweise

ORD-Eintrag
ord-668282ea8a434ec39afca7f89dc75d3b
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06307066B1

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