Ethyl 4,4,4-trifluoroacetoacetate → Ethyl 4,4,4-trifluoro-3-hydroxybutanoate

HRID 381795

Reaktionsgleichung

[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[H][H]>[Pt].C(N(CC)CC)C>[F:1][C:2]([F:11])([F:12])[CH:3]([OH:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

Komponenten

Reaktionsbedingungen

Temperatur: 40 °C

Versuchsvorschrift

Ethyl 4,4,4-trifluoroacetoacetate (350 g), under a blanket of nitrogen gas, was heated to 40° C. and treated with platinum (0.7 g of 5% Pt/C, 0.01% load) and triethylamine (1.5 g, 0.4% load). Hydrogen was charged to a pressure of 5 bars and the mixture agitated at 40° C. for 6h. After filtration to remove the catalyst, 341 g (96% yield) of ethyl 4,4,4-trifluoro-3-hydroxybutyrate was obtained.

Aufarbeitung

filtrationAfter filtration
customto remove the catalyst

Quellen und Nachweise

ORD-Eintrag: ord-e7db54e81976455db6cd5c05ccfe7b32
Quelldatensatz: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06307094B1

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