Ethyl 4,4,4-trifluoroacetoacetate → Ethyl 4,4,4-trifluoro-3-hydroxybutanoate

HRID 381799

Reaktionsgleichung

[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[H][H]>[Pt].C(N(CC)CC)C>[F:1][C:2]([F:11])([F:12])[CH:3]([OH:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

Komponenten

Reaktionsbedingungen

Temperatur: 40 °C

Versuchsvorschrift

Ethyl 4,4,4-trifluoroacetoacetate (50 g), under a blanket of nitrogen gas, is heated to 40° C. and treated with platinum (0.5 g of 1% Pt/C, 0.05% load) and triethylamine (0.2 g, 0.4% load). Hydrogen is charged to a pressure of 5 bars, and the mixture agitated at 40° C. for 6h. After filtration to remove the catalyst, 48.5 g (96% yield) of ethyl 4,4,4-trifluoro-3-hydroxybutyrate is obtained.

Aufarbeitung

filtrationAfter filtration
customto remove the catalyst

Quellen und Nachweise

ORD-Eintrag: ord-b07d5a3524ed43d681a9c5a766d9df0e
Quelldatensatz: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06307094B1

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