HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Carbonate → 4-Hydroxyimino-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | Hydroxyamine hydrochloride | HCID 443297 | — |
| Edukt | 4-Oxo-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid | HCID 23005240 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 4-Hydroxyimino-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid | HCID 86583517 | 60,9% |
Reaktionsschritte
In a manner similar to Example 4, Step (c), 4-oxo-4-(4′-trifluoromethyl-biphenyl-4-yl)-butyric acid (1.20 g, 0.00372 mol) was allowed to react with hydroxylamine hydrochloride (0.3115 g, 0.00448 mol) in the presence of sodium carbonate (0.4768 g, 0.00450 mol) in absolute ethanol (20 mL) to give 0.764 g of 4-hydroxyimino-4-(4′-trifluoromethyl-biphenyl-4-yl)-butyric acid as a white solid; mp 134-136° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06307089B2 |
| Quelldatensatz | uspto-grants-2001_10 |
| ORD ID | ord-5a91edce8afc48488a6e61b0c25d134b |
| Quellennotiz | uspto-grants-2001_10 |