Sodium Carbonate → 4-Hydroxyimino-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid

HRID 381850

Reaktionsgleichung

Reaktionsgleichung von HRID 381850
O=[C:2]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].Cl.[NH2:25][OH:26].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[OH:26][N:25]=[C:2]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6]

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 230052404-Oxo-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acid

Produkt 1

HCID 865835174-Hydroxyimino-4-(4'-trifluoromethyl-biphenyl-4-yl)-butyric acidAusbeute 60,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In a manner similar to Example 4, Step (c), 4-oxo-4-(4′-trifluoromethyl-biphenyl-4-yl)-butyric acid (1.20 g, 0.00372 mol) was allowed to react with hydroxylamine hydrochloride (0.3115 g, 0.00448 mol) in the presence of sodium carbonate (0.4768 g, 0.00450 mol) in absolute ethanol (20 mL) to give 0.764 g of 4-hydroxyimino-4-(4′-trifluoromethyl-biphenyl-4-yl)-butyric acid as a white solid; mp 134-136° C.

Quellen und Nachweise

ORD-Eintrag
ord-5a91edce8afc48488a6e61b0c25d134b
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06307089B2

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