1H-Pyrazol-3-amine, 5-methyl- → (2-chloro-purin-4-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

HRID 38192

Reaktionsgleichung

Reaktionsgleichung von HRID 38192
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[C:9](Cl)([N:10]=1)[N:8]=[CH:7][N:6]=2.[CH3:12][C:13]1[NH:17][N:16]=[C:15]([NH2:18])[CH:14]=1>C(O)C>[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[C:9]([NH:18][C:15]3[CH:14]=[C:13]([CH3:12])[NH:17][N:16]=3)([N:10]=1)[N:8]=[CH:7][N:6]=2

Komponenten

4

Edukt 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 219392112,4-Dichloro-purine

Produkt 1

HCID 21939154(2-chloro-purin-4-yl)-(5-methyl-1H-pyrazol-3-yl)-amineAusbeute 58 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a suspension of 2,4-dichloro-purine (2.0 g, 10.6 mmol) in anhydrous ethanol (10 mL) was added 5-methyl-1H-pyrazol-3-yl amine (2.05 g, 21.2 mmol). The resulting mixture was stirred at room temperature for 48 h. The resulting precipitate was collected by filtration, washed with ethanol, and dried under vacuum to afford 1.524 g (58% yield) of (2-chloro-purin-4-yl)-(5-methyl-1H-pyrazol-3-yl)-amine which was used in the next step without further purification.

Aufarbeitung

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with ethanol
  3. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-05ebf093e1a14231a12db97afd039c30
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524720B2

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