Benzoyl chloride → 1-Benzyl-4-(3,5-dimethylbenzoylamino)-5-imidazolecarboxamide

HRID 382370

Reaktionsgleichung

Reaktionsgleichung von HRID 382370
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].C(Cl)(=O)C1C=CC=CC=1.[CH3:26][C:27]1[CH:28]=[C:29]([CH:33]=[C:34]([CH3:36])[CH:35]=1)[C:30](Cl)=[O:31]>>[CH2:10]([N:5]1[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:30](=[O:31])[C:29]2[CH:33]=[C:34]([CH3:36])[CH:35]=[C:27]([CH3:26])[CH:28]=2)[N:3]=[CH:4]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

4

Edukt 3

HCID 7412Benzoyl chlorideHCID 810883,5-Dimethylbenzoyl ChlorideHCID 140006201-benzyl-4-amino-1H-imidazole-5-carboxamide

Produkt 1

HCID 183603621-Benzyl-4-(3,5-dimethylbenzoylamino)-5-imidazolecarboxamideAusbeute 91 %

Versuchsvorschrift

An amidation reaction and post-treatment were carried out according to the conditions of Example 1, using 6.54 g (30.2 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide prepared in Reference Example 2 and, instead of benzoyl chloride, 3,5-dimethylbenzoyl chloride which was separately prepared by a conventional method, to obtain 9.62 g of 1-benzyl-4-(3,5-dimethylbenzoylamino)-5-imidazolecarboxamide (yield 91%).

Aufarbeitung

  1. customAn amidation reaction
  2. customwas separately prepared by a conventional method

Quellen und Nachweise

ORD-Eintrag
ord-a6bdc99263694f718cdc586144934036
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310070B1

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