3-Pyridineacetic acid, hydrochloride (1:1) → 1-benzyl-4-(3-(N-t-butyloxycarbonyl-N-methylamino)benzoylamino)-5-imidazole carboxamide

Beteiligte Stoffe

Reaktionsschritte

An amidation reaction and post-treatment were carried out under the same conditions as in Example 17, using 0.65 g (3.0 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide which was prepared in the same manner as in Reference Example 2 and 3-(N-t-butyloxycarbonyl-N-methylamino)benzoic acid, instead of 3-pyridylacetic acid hydrochloride, to obtain 1.09 g of 1-benzyl-4-(3-(N-t-butyloxycarbonyl-N-methylamino)benzoylamino)-5-imidazole carboxamide (yield 81%).

Herkunft & Nachweise