2-Fluorobenzoyl chloride → 1-(4-t-Butylbenzyl)-4-(2-fluorobenzoylamino)-5-imidazolecarboxamide

HRID 382398

Reaktionsgleichung

Reaktionsgleichung von HRID 382398
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:21][C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[C:24](Cl)=[O:25]>>[C:17]([C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:5]2[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:24](=[O:25])[C:23]3[CH:27]=[CH:28][CH:29]=[CH:30][C:22]=3[F:21])[N:3]=[CH:4]2)=[CH:12][CH:13]=1)([CH3:20])([CH3:19])[CH3:18]

Komponenten

3

Edukt 2

HCID 98082-Fluorobenzoyl chlorideHCID 183602894-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide

Produkt 1

HCID 183606101-(4-t-Butylbenzyl)-4-(2-fluorobenzoylamino)-5-imidazolecarboxamideAusbeute 89 %

Versuchsvorschrift

An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 1.91 g (7.01 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide which was prepared in the same manner as in Example 57 and 2-fluorobenzoyl chloride instead of benzoyl chloride to obtain 2.47 g of 1-(4-t-butylbenzyl)-4-(2-fluorobenzoylamino)-5-imidazolecarboxamide (yield 89%).

Aufarbeitung

  1. customAn amidation reaction

Quellen und Nachweise

ORD-Eintrag
ord-4bfd908c429048888f86a59332142c35
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310070B1

Verknüpfte Notizen

Wird geladen…