Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- → 1-(4-t-butylbenzyl)-4-(2-(N-t-butyloxycarbonyl-N-methylamino)acetylamino)-5-imidazolecarboxamide

HRID 382407

Reaktionsgleichung

Reaktionsgleichung von HRID 382407
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:21]([O:25][C:26]([N:28]([CH2:30][C:31](O)=[O:32])[CH3:29])=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[C:17]([C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:5]2[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:31](=[O:32])[CH2:30][N:28]([C:26]([O:25][C:21]([CH3:23])([CH3:22])[CH3:24])=[O:27])[CH3:29])[N:3]=[CH:4]2)=[CH:12][CH:13]=1)([CH3:20])([CH3:19])[CH3:18]

Komponenten

3

Edukt 2

HCID 83692Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-HCID 183602894-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide

Produkt 1

HCID 183604101-(4-t-butylbenzyl)-4-(2-(N-t-butyloxycarbonyl-N-methylamino)acetylamino)-5-imidazolecarboxamideAusbeute 80 %

Versuchsvorschrift

An amidation reaction and post-treatment were carried out under the same conditions as in Example 17, using 2.50 g (9.18 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 57 and 2-(N-t-butyloxycarbonyl-N-methylamino)acetic acid instead of 3-pyridylacetic acid hydrochloride to obtain 3.27 g of 1-(4-t-butylbenzyl)-4-(2-(N-t-butyloxycarbonyl-N-methylamino)acetylamino)-5-imidazolecarboxamide (yield 80%).

Aufarbeitung

  1. customAn amidation reaction

Quellen und Nachweise

ORD-Eintrag
ord-d67e24fc3b63487db53ad198a385b8a3
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310070B1

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